Subject：NONLINEAR RAMAN MICROSPECTROSCOPY

Speaker：Prof. VLADISLAV V. YAKOVLEV

Emcee：Prof. Konstantin E. Dorfman

Time：10:00am, 26^th Oct, 2019

Place：Optics Building A408

Abstract：

Progress in the Life Sciences has always depended on the development of new tools and instruments. Our ability to understand the functions of living systems on a cellular and molecular level is greatly enhanced by imaging techniques capable of providing structural and chemical information in vivo. The simplicity, availability, and non-invasiveness of optical methods are attractive features for fundamental physiological studies in small animals, disease diagnosis, image-guided surgery and post-treatment recovery management in patients.

Nonlinear Raman spectroscopy based on coherent anti-Stokes Raman scattering (CARS) is seeing its renaissance these days and sparking a number of new applications in biomedical imaging and sensing. In my presentation I will describe the major physical principles that underlie this increasingly popular nonlinear optical microspectroscopy, outline the major technical innovations that allow this advanced spectroscopic tool to be incorporated in almost any laboratory utilizing short pulsed lasers and discuss its limitations from the standpoint of the signal-to-noise analysis. A careful analysis of those limitations allows designing the most ideal conditions for imaging and bioanalytical spectroscopy. At the end of my lecture I will describe a recently demonstrated intriguing possibility of combining nonlinear Raman excitation with ultrasound detection, which allows reaching a large penetration depth, while preserving chemical specificity and high spatial resolution.

About the Speaker:

Department of Biomedical Engineering

Department of Electrical and Computer Engineering

Department of Physics and Astronomy

Texas A&M University, 5025 Emerging Technologies Building,

EDUCATION: